Ohio River Cruise • View Itinerary
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Ohio River Cruise
Louisville Slugger Museum & Factory, Louisville, Kentucky
Madison, Indiana
Roebling Suspension Bridge, Ohio River
American Heritage, Mississippi Paddleboat, American Cruise Lines
Marietta, Ohio
Ohio River
Duquesne Incline, Pittsburgh
Allegheny River, Roberto Clemente Bridge, Pittsburgh, Pennsylvania USA

Ohio River Cruise

9 day Cruise – from £3980

With flights from £4805

Journey through America’s heartland, enjoying all-inclusive onboard drinks and dining, and a choice of fabulous shore excursions as you go.

Highlights:
  • Take the chance to visit the Muhammad Ali Centre in Louisville
  • Learn about the rich history of Madison
  • Discover Cincinnati’s riverfront and museums
  • Enjoy onboard activities and enterntainment
  • Arrive into Pittsburgh, with its iconic yellow bridges

Your Itinerary

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You can customise your holiday by adding extra nights or activities before or after your Ohio River cruise. Just let us know what you would like to do.

Louisville Slugger Museum & Factory, Louisville, Kentucky

Day 1 – Louisville, Kentucky

Arrive in Louisville, an historic city on the banks of the Ohio River. After dropping your…

Arrive in Louisville, an historic city on the banks of the Ohio River. After dropping your bags off at your hotel, the day is yours to explore at leisure.

You’ll find some of America’s best-loved distilleries along ‘Whiskey Row’, with Evan Williams, Old Forester, Angel’s Envy and others offering tastings and tours.

At the Muhammad Ali Centre you can learn about the life of ‘The Greatest’ who grew up in West Louisville, and at the Slugger Factory & Museum see where baseball bats are handcrafted.

If you would like to add extra nights in Louisville before your Ohio River cruise, just ask.

    Louisville hotel

Louisville Slugger Museum & Factory, Louisville, Kentucky

Day 1

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Louisville, Kentucky

Arrive in Louisville, an historic city on the banks of the Ohio River. After dropping your bags off at your hotel, the day is yours to explore at leisure.

You’ll find some of America’s best-loved distilleries along ‘Whiskey Row’, with Evan Williams, Old Forester, Angel’s Envy and others offering tastings and tours.

At the Muhammad Ali Centre you can learn about the life of ‘The Greatest’ who grew up in West Louisville, and at the Slugger Factory & Museum see where baseball bats are handcrafted.

If you would like to add extra nights in Louisville before your Ohio River cruise, just ask.

    Louisville hotel

Louisville Slugger Museum & Factory, Louisville, Kentucky
Ohio River Cruise

Day 2 – Day of Cruising

Board your Ohio River cruise ship and get to know your fellow guests at a Welcome…

Board your Ohio River cruise ship and get to know your fellow guests at a Welcome Reception.

Enjoy a scenic afternoon cruising the picturesque Ohio River, passing small towns, wooded landscapes and rolling hills.Relax on deck, or find a cosy corner in one of the lounges.

    On board

    All meals on board
Ohio River Cruise

Day 2

|

Day of Cruising

Board your Ohio River cruise ship and get to know your fellow guests at a Welcome Reception.

Enjoy a scenic afternoon cruising the picturesque Ohio River, passing small towns, wooded landscapes and rolling hills.Relax on deck, or find a cosy corner in one of the lounges.

    On board

    All meals on board
Ohio River Cruise
Madison, Indiana

Day 3 – Madison, Indiana

A historic town on the banks of the Ohio River, Madison is known for its well-preserved…

A historic town on the banks of the Ohio River, Madison is known for its well-preserved 19th century architecture. The historic district, listed on the National Register of Historic Places, includes more than 130 buildings representing Greek Revival, Victorian and Federal styles.

Madison also played a role in the Underground Railroad, with several local sites linked to the abolitionist movement. The town hosts the annual Madison Regatta, one of the oldest hydroplane races in the United States.

Spend time exploring the compact downtown area, home to independent shops, galleries and restaurants.

    On board

    All meals on board
Madison, Indiana

Day 3

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Madison, Indiana

A historic town on the banks of the Ohio River, Madison is known for its well-preserved 19th century architecture. The historic district, listed on the National Register of Historic Places, includes more than 130 buildings representing Greek Revival, Victorian and Federal styles.

Madison also played a role in the Underground Railroad, with several local sites linked to the abolitionist movement. The town hosts the annual Madison Regatta, one of the oldest hydroplane races in the United States.

Spend time exploring the compact downtown area, home to independent shops, galleries and restaurants.

    On board

    All meals on board
Madison, Indiana
Roebling Suspension Bridge, Ohio River

Day 4 – Cincinnati, Ohio

Cross the Ohio River into Cincinnati, welcomed by the city’s distinctive bridges and riverfront skyline. Once…

Cross the Ohio River into Cincinnati, welcomed by the city’s distinctive bridges and riverfront skyline. Once a major centre for shipbuilding and trade, Cincinnati earned the nickname ‘Queen City.’

Today, it is a city with professional sports teams, a fantastic zoo and botanical garden, and a range of theatres and museums, including the National Underground Railroad Freedom Center.

Explore the city at your own pace. Visit highlights such as the Krohn Conservatory and St. Mary’s Cathedral Basilica, or sample local favourites including Cincinnati Skyline Chili and Graeter’s ice cream, established in 1868.

    On board

    All meals on board
Roebling Suspension Bridge, Ohio River

Day 4

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Cincinnati, Ohio

Cross the Ohio River into Cincinnati, welcomed by the city’s distinctive bridges and riverfront skyline. Once a major centre for shipbuilding and trade, Cincinnati earned the nickname ‘Queen City.’

Today, it is a city with professional sports teams, a fantastic zoo and botanical garden, and a range of theatres and museums, including the National Underground Railroad Freedom Center.

Explore the city at your own pace. Visit highlights such as the Krohn Conservatory and St. Mary’s Cathedral Basilica, or sample local favourites including Cincinnati Skyline Chili and Graeter’s ice cream, established in 1868.

    On board

    All meals on board
Roebling Suspension Bridge, Ohio River
American Heritage, Mississippi Paddleboat, American Cruise Lines

Day 5 – Day of Cruising

Spend the day cruising along the Ohio River, taking in views of wooded riverbanks and small…

Spend the day cruising along the Ohio River, taking in views of wooded riverbanks and small towns visible from the deck.

On board, a programme of activities and talks provides further insight into the region’s history and culture.

    On board

    All meals on board
American Heritage, Mississippi Paddleboat, American Cruise Lines

Day 5

|

Day of Cruising

Spend the day cruising along the Ohio River, taking in views of wooded riverbanks and small towns visible from the deck.

On board, a programme of activities and talks provides further insight into the region’s history and culture.

    On board

    All meals on board
American Heritage, Mississippi Paddleboat, American Cruise Lines
Marietta, Ohio

Day 6 – Marietta, Ohio

Located at the confluence of the Muskingum and Ohio Rivers, Marietta is a historic town with…

Located at the confluence of the Muskingum and Ohio Rivers, Marietta is a historic town with five National Register Historic Districts and buildings dating back to its founding in 1788. It was the first permanent settlement in the Northwest Territory north of the Ohio River.

During your visit, learn about the town’s early history and the events that shaped the region, as detailed in The Pioneers by Pulitzer Prize-winning historian David McCullough.

    On board

    All meals on board
Marietta, Ohio

Day 6

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Marietta, Ohio

Located at the confluence of the Muskingum and Ohio Rivers, Marietta is a historic town with five National Register Historic Districts and buildings dating back to its founding in 1788. It was the first permanent settlement in the Northwest Territory north of the Ohio River.

During your visit, learn about the town’s early history and the events that shaped the region, as detailed in The Pioneers by Pulitzer Prize-winning historian David McCullough.

    On board

    All meals on board
Marietta, Ohio
Ohio River

Day 7 – Day of Cruising

Spend the day cruising through the Appalachian foothills, passing wooded landscapes, river valleys and small towns…

Spend the day cruising through the Appalachian foothills, passing wooded landscapes, river valleys and small towns along the way. This stretch of river offers a mix of rural scenery and changing terrain.

As you approach Pittsburgh, the city’s skyline and well-known bridges come into view at the meeting point of the Allegheny and Monongahela rivers. The contrast between the surrounding countryside and the city reflects Pittsburgh’s industrial heritage alongside its modern development.

    Onboard

    All meals on board
Ohio River

Day 7

|

Day of Cruising

Spend the day cruising through the Appalachian foothills, passing wooded landscapes, river valleys and small towns along the way. This stretch of river offers a mix of rural scenery and changing terrain.

As you approach Pittsburgh, the city’s skyline and well-known bridges come into view at the meeting point of the Allegheny and Monongahela rivers. The contrast between the surrounding countryside and the city reflects Pittsburgh’s industrial heritage alongside its modern development.

    Onboard

    All meals on board
Ohio River
Duquesne Incline, Pittsburgh

Day 8 – Pittsburgh, Pennsylvania

Dock near the point where the Allegheny and Monongahela Rivers meet to form the Ohio River. Known…

Dock near the point where the Allegheny and Monongahela Rivers meet to form the Ohio River.

Known for its steel industry, Pittsburgh was an important centre for trade during the 18th and 19th centuries and played a key role in national and international commerce. Learn about influential figures such as Heinz and Carnegie, who were closely connected to the city’s development.

    On board

    All meals on board
Duquesne Incline, Pittsburgh

Day 8

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Pittsburgh, Pennsylvania

Dock near the point where the Allegheny and Monongahela Rivers meet to form the Ohio River.

Known for its steel industry, Pittsburgh was an important centre for trade during the 18th and 19th centuries and played a key role in national and international commerce. Learn about influential figures such as Heinz and Carnegie, who were closely connected to the city’s development.

    On board

    All meals on board
Duquesne Incline, Pittsburgh
Allegheny River, Roberto Clemente Bridge, Pittsburgh, Pennsylvania USA

Day 9 – Depart Pittsburgh

Enjoy breakfast on board the ship, before beginning your journey home. Reflect upon your adventures and…

Enjoy breakfast on board the ship, before beginning your journey home. Reflect upon your adventures and the new friends made along the way.

    Breakfast on board
Allegheny River, Roberto Clemente Bridge, Pittsburgh, Pennsylvania USA

Day 9

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Depart Pittsburgh

Enjoy breakfast on board the ship, before beginning your journey home. Reflect upon your adventures and the new friends made along the way.

    Breakfast on board
Allegheny River, Roberto Clemente Bridge, Pittsburgh, Pennsylvania USA

This Cruise Holiday Includes

1 night hotel accommodation
7 night cruise
All meals on board the cruise
Soft drinks and selected beers and wines on board
A range of complimentary and optional shore excursions
Onboard entertainment

Departure Dates

Check for departure dates that suit you:

2027-07-18

2027-07-26

2027-08-03

2027-08-11

2027-08-19

2028-07-16

2028-07-24

2028-08-01

2028-08-09

2028-08-17

2028-08-25

2028-09-02

2028-09-18

To confirm availability call 0333 234 0922

Flights & More Options

With FREEDOM, you can book your Ohio River Cruise and flights together, as an ATOL protected package. Our Travel Experts can find the best priced Economy, Premium or Business Class flights for you.

You can also personalise your holiday. Popular options include:

  • Extra nights in Louisville or Pittsburgh
  • A Philadelphia or New York city stay

Next Step

Please get in touch with our America Experts to start planning your holiday. You’ll have a single point of contact from your first enquiry through booking.

Ohio River Cruise

9 day Cruise – from £3980

With flights from £4805

Map

Ohio River Cruise Route Map

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