The Deluxe King Rooms are modern and comfortable, with a king-size bed and clean, contemporary design. Each room includes thoughtful touches and subtle artistic details, overlooking the hotel’s atrium.

The Luxury King Rooms offer a more spacious and refined stay, featuring a king-sized bed, city views of downtown Louisville, and original artworks on display. With modern design, stylish furnishings and thoughtful details throughout, they provide a comfortable and slightly more elevated space to unwind.

The Corner Suites are the hotel’s largest rooms, offering plenty of space to relax and unwind. Each suite features a king-sized bed, along with separate living and dining areas for added comfort. Large windows on multiple sides provide views over 7th Street, Main Street, and the Ohio River, filling the space with natural light.

Proof on Main is one of Louisville’s most iconic dining spots, known for its creative take on Southern and Appalachian-inspired cuisine. The restaurant blends locally sourced ingredients with global influences, while the adjoining lounge is home to the 21c Selects Private Barrel Program and is widely regarded as one of the best bourbon bars in the country.

The museum at 21c Museum Hotel Louisville is a contemporary art space spread throughout the property, featuring rotating exhibitions from international artists. Open 24 hours a day and free to the public, it offers an immersive experience where thought-provoking installations, sculptures, and multimedia works are integrated into the hotel’s public areas, creating a unique experience.

Guests can relax at the on-site spa, which offers a variety of treatments including massages, or make use of the 24-hour fitness centre. There’s also free Wi-Fi throughout the hotel, along with convenient services such as a 24-hour front desk, room service, and business facilities. Additional touches like pet-friendly stays, bicycle hire, and comfortable communal spaces help create a well-rounded stay, blending relaxation, practicality, and a touch of luxury.